| EC |
2.7.9.4 |
| Accepted name: |
α-glucan, water dikinase |
| Reaction: |
ATP + α-glucan + H2O = AMP + phospho-α-glucan + phosphate |
| Other name(s): |
starch-related R1 protein; GWD |
| Systematic name: |
ATP:α-glucan, water phosphotransferase |
| Comments: |
Requires Mg2+. ATP appears to be the only phosphate donor. No activity could be detected using GTP, UTP, phosphoenolpyruvate or diphosphate [1]. The protein phosphorylates glucans exclusively on O-6 of glucosyl residues [2]. The protein phosphorylates itself with the β-phosphate of ATP, which is then transferred to the glucan [1]. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 664327-94-0 |
| References: |
| 1. |
Ritte, G., Lloyd, J.R., Eckermann, N., Rottmann, A., Kossmann, J. and Steup, M. The starch-related R1 protein is an α-glucan, water dikinase. Proc. Natl. Acad. Sci. USA 99 (2002) 7166–7171. [DOI] [PMID: 12011472] |
| 2. |
Ritte, G., Heydenreich, M., Mahlow, S., Haebel, S., Kötting, O. and Steup, M. Phosphorylation of C6- and C3-positions of glucosyl residues in starch is catalysed by distinct dikinases. FEBS Lett. 580 (2006) 4872–4876. [DOI] [PMID: 16914145] |
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| [EC 2.7.9.4 created 2002] |
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