The Enzyme Database

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Accepted name: N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
Reaction: (1) 3′-phospho-5′-adenylyl sulfate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine = adenosine 3′,5′-bisphosphate + [dermatan]-4,6-di-O-sulfo-N-acetyl-D-galactosamine
(2) 3′-phospho-5′-adenylyl sulfate + [chondroitin]-4-O-sulfo-N-acetyl-D-galactosamine = adenosine 3′,5′-bisphosphate + [chondroitin]-4,6-di-O-sulfo-N-acetyl-D-galactosamine
Other name(s): GalNAc4S-6ST; CHST15 (gene name); 3′-phosphoadenylyl-sulfate:[dermatan]-4-O-sulfo-N-acetyl-D-galactosamine 6-O-sulfotransferase
Systematic name: 3′-phosphoadenylyl-sulfate:[dermatan]-4-O-sulfo-N-acetyl-D-galactosamine 6-O-sulfonotransferase
Comments: The enzyme is activated by divalent cations and reduced glutathione. The enzyme from human transfers sulfate to position 6 of both internal residues and non-reducing terminal GalNAc 4-sulfate residues of chondroitin sulfate and dermatan sulfate. Oligosaccharides derived from chondroitin sulfate also serve as acceptors but chondroitin sulfate E, keratan sulfate and heparan sulfate do not. Differs from EC, chondroitin 6-sulfotransferase, in being able to use both chondroitin and dermatan as effective substrates
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 242469-38-1
1.  Ito, Y. and Habuchi, O. Purification and characterization of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase from the squid cartilage. J. Biol. Chem. 275 (2000) 34728–34736. [DOI] [PMID: 10871629]
2.  Ohtake, S., Ito, Y., Fukuta, M. and Habuchi, O. Human N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase cDNA is related to human B cell recombination activating gene-associated gene. J. Biol. Chem. 276 (2001) 43894–43900. [DOI] [PMID: 11572857]
[EC created 2005, modified 2010]

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