| EC |
2.8.2.36 |
| Accepted name: |
desulfo-A47934 sulfotransferase |
| Reaction: |
3′-phosphoadenylyl sulfate + desulfo-A47934 = adenosine 3′,5′-bisphosphate + A47934 |
| Glossary: |
desulfo-A47934 = LY 154989 = 7-demethyl-64-O-demethyl-19-deoxy-22,31,45-trichloro-11-sulfo-ristomycin A aglycone
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| Other name(s): |
StaL; 3′-phosphoadenylyl-sulfate:desulfo-A47934 sulfotransferase |
| Systematic name: |
3′-phosphoadenylyl-sulfate:desulfo-A47934 sulfonotransferase |
| Comments: |
The enzyme from the bacterium Streptomyces toyocaensis catalyses the final step in the biosynthesis of the glycopeptide antibiotic A47934, a naturally occuring antibiotic of the vancomycin group. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Lamb, S.S., Patel, T., Koteva, K.P. and Wright, G.D. Biosynthesis of sulfated glycopeptide antibiotics by using the sulfotransferase StaL. Chem. Biol. 13 (2006) 171–181. [DOI] [PMID: 16492565] |
| 2. |
Shi, R., Lamb, S.S., Bhat, S., Sulea, T., Wright, G.D., Matte, A. and Cygler, M. Crystal structure of StaL, a glycopeptide antibiotic sulfotransferase from Streptomyces toyocaensis. J. Biol. Chem. 282 (2007) 13073–13086. [DOI] [PMID: 17329243] |
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| [EC 2.8.2.36 created 2014] |
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