The Enzyme Database

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Accepted name: succinate—hydroxymethylglutarate CoA-transferase
Reaction: succinyl-CoA + 3-hydroxy-3-methylglutarate = succinate + (S)-3-hydroxy-3-methylglutaryl-CoA
For diagram of mevalonate biosynthesis, click here
Other name(s): hydroxymethylglutarate coenzyme A-transferase; dicarboxyl-CoA:dicarboxylic acid coenzyme A transferase
Systematic name: succinyl-CoA:3-hydroxy-3-methylglutarate CoA-transferase
Comments: Malonyl-CoA can also act as donor, but more slowly.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 80237-90-7
1.  Deana, R., Rigoni, F., Deana, A.D. and Galzigna, L. Submitochondrial localization and partial purification of the succinyl CoA: 3-hydroxy-3-methylglutarate coenzyme A transferase from rat liver. Biochim. Biophys. Acta 662 (1981) 119–124. [DOI] [PMID: 6946836]
[EC created 1984]

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