| EC |
2.8.3.18 |
| Accepted name: |
succinyl-CoA:acetate CoA-transferase |
| Reaction: |
succinyl-CoA + acetate = acetyl-CoA + succinate |
| Other name(s): |
aarC (gene name); SCACT |
| Systematic name: |
succinyl-CoA:acetate CoA-transferase |
| Comments: |
In some bacteria the enzyme catalyses the conversion of acetate to acetyl-CoA as part of a modified tricarboxylic acid (TCA) cycle [3,5,6]. In other organisms it converts acetyl-CoA to acetate during fermentation [1,2,4,7]. In some organisms the enzyme also catalyses the activity of EC 2.8.3.27, propanoyl-CoA:succinate CoA transferase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Steinbuchel, A. and Muller, M. Anaerobic pyruvate metabolism of Tritrichomonas foetus and Trichomonas vaginalis hydrogenosomes. Mol. Biochem. Parasitol. 20 (1986) 57–65. [DOI] [PMID: 3090435] |
| 2. |
Sohling, B. and Gottschalk, G. Molecular analysis of the anaerobic succinate degradation pathway in Clostridium kluyveri. J. Bacteriol. 178 (1996) 871–880. [DOI] [PMID: 8550525] |
| 3. |
Mullins, E.A., Francois, J.A. and Kappock, T.J. A specialized citric acid cycle requiring succinyl-coenzyme A (CoA):acetate CoA-transferase (AarC) confers acetic acid resistance on the acidophile Acetobacter aceti. J. Bacteriol. 190 (2008) 4933–4940. [DOI] [PMID: 18502856] |
| 4. |
van Grinsven, K.W., van Hellemond, J.J. and Tielens, A.G. Acetate:succinate CoA-transferase in the anaerobic mitochondria of Fasciola hepatica. Mol. Biochem. Parasitol. 164 (2009) 74–79. [DOI] [PMID: 19103231] |
| 5. |
Mullins, E.A. and Kappock, T.J. Crystal structures of Acetobacter aceti succinyl-coenzyme A (CoA):acetate CoA-transferase reveal specificity determinants and illustrate the mechanism used by class I CoA-transferases. Biochemistry 51 (2012) 8422–8434. [DOI] [PMID: 23030530] |
| 6. |
Kwong, W.K., Zheng, H. and Moran, N.A. Convergent evolution of a modified, acetate-driven TCA cycle in bacteria. Nat Microbiol 2:17067 (2017). [DOI] [PMID: 28452983] |
| 7. |
Zhang, B., Lingga, C., Bowman, C. and Hackmann, T.J. A new pathway for forming acetate and synthesizing ATP during fermentation in bacteria. Appl. Environ. Microbiol. 87 (2021) e0295920. [DOI] [PMID: 33931420] |
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| [EC 2.8.3.18 created 2013, modified 2022] |
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