EC |
2.8.3.24 |
Accepted name: |
(R)-2-hydroxy-4-methylpentanoate CoA-transferase |
Reaction: |
4-methylpentanoyl-CoA + (R)-2-hydroxy-4-methylpentanoate = 4-methylpentanoate + (R)-2-hydroxy-4-methylpentanoyl-CoA |
Glossary: |
4-methylpentanoate = isocaproate |
Other name(s): |
hadA (gene name) |
Systematic name: |
4-methylpentanoyl-CoA:(R)-2-hydroxy-4-methylpentanoate CoA-transferase |
Comments: |
The enzyme, characterized from the bacterium Peptoclostridium difficile, participates in an L-leucine fermentation pathway. The reaction proceeds via formation of a covalent anhydride intermediate between a conserved aspartate residue and the acyl group of the CoA thioester substrate. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Kim, J., Darley, D., Selmer, T. and Buckel, W. Characterization of (R)-2-hydroxyisocaproate dehydrogenase and a family III coenzyme A transferase involved in reduction of L-leucine to isocaproate by Clostridium difficile. Appl. Environ. Microbiol. 72 (2006) 6062–6069. [DOI] [PMID: 16957230] |
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[EC 2.8.3.24 created 2016] |
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