The Enzyme Database

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EC 2.8.3.28     
Accepted name: phenylsuccinyl-CoA transferase
Reaction: (1) phenylsuccinate + succinyl-CoA = 2-phenylsuccinyl-CoA + succinate
(2) phenylsuccinate + succinyl-CoA = 3-phenylsuccinyl-CoA + succinate
Other name(s): iaaL (gene name)
Systematic name: succinyl-CoA:2/3-phenylsuccinate CoA-transferase
Comments: The enzyme, characterized from the bacterium Aromatoleum aromaticum, is involved in degradation of (indol-3-yl)acetate, where it is believed to function on (2-aminophenyl)succinate. It has a broad substrate specificity towards other C4-dicarboxylic acids, phenylacetate, and the non-physiological compound 2-naphthylacetate. The enzyme produces 2- and 3-phenylsuccinyl-CoA in equimolar amounts. It can also perform an intramolecular transfer of the CoA moiety to convert 2-phenylsuccinyl-CoA to 3-phenylsuccinyl-CoA.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Schuhle, K., Nies, J. and Heider, J. An indoleacetate-CoA ligase and a phenylsuccinyl-CoA transferase involved in anaerobic metabolism of auxin. Environ. Microbiol. 18 (2016) 3120–3132. [DOI] [PMID: 27102732]
[EC 2.8.3.28 created 2022]
 
 


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