| EC |
2.8.4.2 |
| Accepted name: |
arsenate-mycothiol transferase |
| Reaction: |
arsenate + mycothiol = arseno-mycothiol + H2O |
| Glossary: |
mycothiol = 1-O-[2-(N2-acetyl-L-cysteinamido)-2-deoxy--D-glucopyranosyl]-1D-myo-inositol |
| Other name(s): |
ArsC1; ArsC2; mycothiol:arsenate transferase |
| Systematic name: |
mycothiol:arsenate S-arsenotransferase |
| Comments: |
Reduction of arsenate is part of a defence mechanism of the cell against toxic arsenate. The product arseno-mycothiol is reduced by EC 1.20.4.3 (mycoredoxin) to arsenite and mycothiol-mycoredoxin disulfide. Finally, a second mycothiol recycles mycoredoxin and forms mycothione. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Ordonez, E., Van Belle, K., Roos, G., De Galan, S., Letek, M., Gil, J.A., Wyns, L., Mateos, L.M. and Messens, J. Arsenate reductase, mycothiol, and mycoredoxin concert thiol/disulfide exchange. J. Biol. Chem. 284 (2009) 15107–15116. [DOI] [PMID: 19286650] |
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| [EC 2.8.4.2 created 2010] |
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