| EC |
3.1.1.126 |
| Accepted name: |
L-galactono-1,5-lactonase |
| Reaction: |
L-galactono-1,5-lactone + H2O = L-galactonate |
| Other name(s): |
lgaB (gene name); Bvu0220 |
| Systematic name: |
L-glucono-1,5-lactone lactonohydrolase |
| Comments: |
The enzyme catalyses a step in the bacterial L-galactose utilization metabolic pathway. The upstream enzyme, EC 1.1.1.445 L-galactose 1-dehydrogenase (NADP+), produces L-galactono-1,5-lactone, which is spontaneously converted to L-galactono-1,4-lactone. However, the enzyme from Phocaeicola vulgatus hydrolyses L-galactono-1,5-lactone 300-fold faster than L-galactono-1,4-lactone. The product, L-galactonate, is further degraded by L-galactonate 5-dehydrogenase (EC 1.1.1.414). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Hobbs, M.E., Williams, H.J., Hillerich, B., Almo, S.C. and Raushel, F.M. L-Galactose metabolism in Bacteroides vulgatus from the human gut microbiota. Biochemistry 53 (2014) 4661–4670. [DOI] [PMID: 24963813] |
|
| [EC 3.1.1.126 created 2026] |
| |
|
| |
|
Printable version