| EC |
3.1.1.25 |
| Accepted name: |
1,4-lactonase |
| Reaction: |
a 1,4-lactone + H2O = a 4-hydroxyacid |
| Other name(s): |
γ-lactonase |
| Systematic name: |
1,4-lactone hydroxyacylhydrolase |
| Comments: |
The enzyme is specific for 1,4-lactones with 4-8 carbon atoms. It does not hydrolyse simple aliphatic esters, acetylcholine, sugar lactones or substituted aliphatic lactones, e.g. 3-hydroxy-4-butyrolactone; requires Ca2+. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37278-38-9 |
| References: |
| 1. |
Fishbein, W.N. and Bessman, S.P. Purification and properties of an enzyme in human blood and rat liver microsomes catalyzing the formation and hydrolysis of γ-lactones. I. Tissue localization, stoichiometry, specificity, distinction from esterase. J. Biol. Chem. 241 (1966) 4835–4841. [PMID: 4958984] |
| 2. |
Fishbein, W.N. and Bessman, S.P. Purification and properties of an enzyme in human blood and rat liver microsomes catalyzing the formation and hydrolysis of γ-lactones. II. Metal ion effects, kinetics, and equilibria. J. Biol. Chem. 241 (1966) 4842–4847. [PMID: 4958985] |
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| [EC 3.1.1.25 created 1972, modified 1981] |
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