The Enzyme Database

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Accepted name: lipoprotein lipase
Reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate
Other name(s): clearing factor lipase; diacylglycerol lipase; postheparin esterase; diglyceride lipase; postheparin lipase; diacylglycerol hydrolase; lipemia-clearing factor; hepatic triacylglycerol lipase; LIPC (gene name); LPL (gene name); triacylglycero-protein acylhydrolase
Systematic name: triacylglycerol acylhydrolase (lipoprotein-dependent)
Comments: Hydrolyses triacylglycerols and diacylglycerol in chylomicrons and low-density lipoprotein particles. Human protein purified from post-heparin plasma (LPL) shows no activity against triglyceride in the absence of added lipoprotein. The principal reaction sequence of that enzyme is triglyceride → 1,2-diglyceride → 2-monoglyceride. The hepatic enzyme (LIPC) also hydrolyses triglycerides and phospholipids present in circulating plasma lipoproteins.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9004-02-8
1.  Egelrud, T. and Olivecrona, T. Purified bovine milk (lipoprotein) lipase: activity against lipid substrates in the absence of exogenous serum factors. Biochim. Biophys. Acta 306 (1973) 115–127. [DOI] [PMID: 4703566]
2.  Fielding, C.J. Human lipoprotein lipase. I. Purification and substrate specificity. Biochim. Biophys. Acta 206 (1970) 109–117. [DOI] [PMID: 5441398]
3.  Greten, H., Levy, R.I., Fales, H. and Fredrickson, D.S. Hydrolysis of diglyceride and glyceryl monoester diethers with lipoprotein lipase. Biochim. Biophys. Acta 210 (1970) 39–45. [DOI] [PMID: 5466051]
4.  Morley, N. and Kuksis, A. Positional specificity of lipoprotein lipase. J. Biol. Chem. 247 (1972) 6389–6393. [PMID: 5076762]
5.  Nilsson-Ehle, P., Belfrage, P. and Borgström, B. Purified human lipoprotein lipase: positional specificity. Biochim. Biophys. Acta 248 (1971) 114–120. [DOI] [PMID: 5168777]
6.  Santamarina-Fojo, S., Gonzalez-Navarro, H., Freeman, L., Wagner, E. and Nong, Z. Hepatic lipase, lipoprotein metabolism, and atherogenesis. Arterioscler Thromb Vasc Biol 24 (2004) 1750–1754. [PMID: 15284087]
[EC created 1972, modified 1976]

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