| EC |
3.1.1.34 |
| Accepted name: |
lipoprotein lipase |
| Reaction: |
triacylglycerol + H2O = diacylglycerol + a carboxylate |
| Other name(s): |
clearing factor lipase; diacylglycerol lipase; postheparin esterase; diglyceride lipase; postheparin lipase; diacylglycerol hydrolase; lipemia-clearing factor; hepatic triacylglycerol lipase; LIPC (gene name); LPL (gene name); triacylglycero-protein acylhydrolase |
| Systematic name: |
triacylglycerol acylhydrolase (lipoprotein-dependent) |
| Comments: |
Hydrolyses triacylglycerols and diacylglycerol in chylomicrons and low-density lipoprotein particles. Human protein purified from post-heparin plasma (LPL) shows no activity against triglyceride in the absence of added lipoprotein. The principal reaction sequence of that enzyme is triglyceride → 1,2-diglyceride → 2-monoglyceride. The hepatic enzyme (LIPC) also hydrolyses triglycerides and phospholipids present in circulating plasma lipoproteins. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9004-02-8 |
| References: |
| 1. |
Egelrud, T. and Olivecrona, T. Purified bovine milk (lipoprotein) lipase: activity against lipid substrates in the absence of exogenous serum factors. Biochim. Biophys. Acta 306 (1973) 115–127. [DOI] [PMID: 4703566] |
| 2. |
Fielding, C.J. Human lipoprotein lipase. I. Purification and substrate specificity. Biochim. Biophys. Acta 206 (1970) 109–117. [DOI] [PMID: 5441398] |
| 3. |
Greten, H., Levy, R.I., Fales, H. and Fredrickson, D.S. Hydrolysis of diglyceride and glyceryl monoester diethers with lipoprotein lipase. Biochim. Biophys. Acta 210 (1970) 39–45. [DOI] [PMID: 5466051] |
| 4. |
Morley, N. and Kuksis, A. Positional specificity of lipoprotein lipase. J. Biol. Chem. 247 (1972) 6389–6393. [PMID: 5076762] |
| 5. |
Nilsson-Ehle, P., Belfrage, P. and Borgström, B. Purified human lipoprotein lipase: positional specificity. Biochim. Biophys. Acta 248 (1971) 114–120. [DOI] [PMID: 5168777] |
| 6. |
Santamarina-Fojo, S., Gonzalez-Navarro, H., Freeman, L., Wagner, E. and Nong, Z. Hepatic lipase, lipoprotein metabolism, and atherogenesis. Arterioscler Thromb Vasc Biol 24 (2004) 1750–1754. [PMID: 15284087] |
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| [EC 3.1.1.34 created 1972, modified 1976] |
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