| EC |
3.1.1.4 |
| Accepted name: |
phospholipase A2 |
| Reaction: |
phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate |
| Other name(s): |
lecithinase A; phosphatidase; phosphatidolipase; phospholipase A |
| Systematic name: |
phosphatidylcholine 2-acylhydrolase |
| Comments: |
Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position. Requires Ca2+. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9001-84-7 |
| References: |
| 1. |
Doery, H.M. and Pearson, J.E. Haemolysins in venoms of Australian snakes. Observations on the haemolysins of the venoms of some Australian snakes and the separation of phospholipase A from the venom of Pseudechis porphyriacus. Biochem. J. 78 (1961) 820–827. [PMID: 13723433] |
| 2. |
Fraenkel-Conrat, H. and Fraenkel-Conrat, J. Inactivation of crotoxin by group-specific reagents. Biochim. Biophys. Acta 5 (1950) 98–104. [DOI] [PMID: 15433984] |
| 3. |
Hanahan, D.J., Brockerhoff, H. and Barron, E.J. The site of attack of phospholipase (lecithinase) A on lecithin: a re-evaluation. Position of fatty acids on lecithins and triglycerides. J. Biol. Chem. 235 (1960) 1917–1923. [PMID: 14399412] |
| 4. |
Moore, J.H. and Williams, D.L. Some observations on the specificity of phospholipase A. Biochim. Biophys. Acta 84 (1964) 41–54. [PMID: 14124755] |
| 5. |
Saito, K. and Hanahan, D.J. A study of the purification and properties of the phospholipase A of Crotalus adamanteus venom. Biochemistry 1 (1962) 521–532. [PMID: 14496116] |
| 6. |
van den Bosch, H. Intracellular phospholipases A. Biochim. Biophys. Acta 604 (1980) 191–246. [DOI] [PMID: 6252969] |
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| [EC 3.1.1.4 created 1961, modified 1976, modified 1983] |
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