The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

Accepted name: phorbol-diester hydrolase
Reaction: phorbol 12,13-dibutanoate + H2O = phorbol 13-butanoate + butanoate
For diagram of reaction, click here
Other name(s): diacylphorbate 12-hydrolase; diacylphorbate 12-hydrolase; phorbol-12,13-diester 12-ester hydrolase; PDEH
Systematic name: 12,13-diacylphorbate 12-acylhydrolase
Comments: Hydrolyses the 12-ester bond in a variety of 12,13-diacylphorbols (phorbol is a diterpenoid); this reaction inactivates the tumour promotor 12-O-tetradecanoylphorbol-13-acetate from croton oil.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 81181-74-0
1.  Shoyab, M., Warren, T.C. and Todaro, G.J. Isolation and characterization of an ester hydrolase active on phorbol diesters from murine liver. J. Biol. Chem. 256 (1981) 12529–12534. [PMID: 6946062]
[EC created 1984]

Data © 2001–2024 IUBMB
Web site © 2005–2024 Andrew McDonald