ExplorEnz: EC 3.1.1.83

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3.1.1.83

Accepted name:

monoterpene ε-lactone hydrolase

Reaction:

(1) isoprop(en)ylmethyloxepan-2-one + H₂O = 6-hydroxyisoprop(en)ylmethylhexanoate (general reaction)
(2) 4-isopropenyl-7-methyloxepan-2-one + H₂O = 6-hydroxy-3-isopropenylheptanoate
(3) 7-isopropyl-4-methyloxepan-2-one + H₂O = 6-hydroxy-3,7-dimethyloctanoate

For diagram of (–)-carvone catabolism, click here and for diagram of menthol biosynthesis, click here

Other name(s):

MLH

Systematic name:

isoprop(en)ylmethyloxepan-2-one lactonohydrolase

Comments:

The enzyme catalyses the ring opening of ε-lactones which are formed during degradation of dihydrocarveol by the Gram-positive bacterium Rhodococcus erythropolis DCL14. The enzyme also acts on ethyl caproate, indicating that it is an esterase with a preference for lactones (internal cyclic esters). The enzyme is not stereoselective.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc

References:

1.	van der Vlugt-Bergmans , C.J. and van der Werf , M.J. Genetic and biochemical characterization of a novel monoterpene ε-lactone hydrolase from Rhodococcus erythropolis DCL14. Appl. Environ. Microbiol. 67 (2001) 733–741. [DOI] [PMID: 11157238]

[EC 3.1.1.83 created 2008]