| EC |
3.1.11.3 |
| Accepted name: |
exodeoxyribonuclease (lambda-induced) |
| Reaction: |
Exonucleolytic cleavage in the 5′- to 3′-direction to yield nucleoside 5′-phosphates |
| Other name(s): |
lambda exonuclease; phage lambda-induced exonuclease; Escherichia coli exonuclease IV; E. coli exonuclease IV; exodeoxyribonuclease IV; exonuclease IV |
| Comments: |
Preference for double-stranded DNA. Does not attack single-strand breaks. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37367-70-7 |
| References: |
| 1. |
Lindahl, T., Gally, J.A. and Edelman, G.M. Deoxyribonuclease IV: a new exonuclease from mammalian tissues. Proc. Natl. Acad. Sci. USA 62 (1969) 597–603. [DOI] [PMID: 5256235] |
| 2. |
Little, J.W. An exonuclease induced by bacteriophage lambda. II. Nature of the enzymatic reaction. J. Biol. Chem. 242 (1967) 679–686. [PMID: 6017737] |
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| [EC 3.1.11.3 created 1972 as EC 3.1.4.28, transferred 1978 to EC 3.1.11.3] |
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