| EC |
3.1.11.5 |
| Accepted name: |
exodeoxyribonuclease V |
| Reaction: |
Exonucleolytic cleavage (in the presence of ATP) in either 5′- to 3′- or 3′- to 5′-direction to yield 5′-phosphooligonucleotides |
| Other name(s): |
Escherichia coli exonuclease V; E. coli exonuclease V; gene recBC endoenzyme; RecBC deoxyribonuclease; gene recBC DNase; exonuclease V; gene recBCD enzymes |
| Comments: |
Preference for double-stranded DNA. Possesses DNA-dependent ATPase activity. Acts endonucleolytically on single-stranded circular DNA. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 37350-26-8 |
| References: |
| 1. |
Eichler, D.C. and Lehman, I.R. On the role of ATP in phosphodiester bond hydrolysis catalyzed by the recBC deoxyribonuclease of Escherichia coli. J. Biol. Chem. 252 (1977) 499–503. [PMID: 319095] |
| 2. |
Goldmark, P.J. and Liun, S. Purification and properties of the recBC DNase of Escherichia coli K-12. J. Biol. Chem. 247 (1972) 1849–1860. [PMID: 4552016] |
| 3. |
Oishi, M. An ATP-dependent deoxyribonuclease from Escherichia coli with a possible role in genetic recombination. Proc. Natl. Acad. Sci. USA 64 (1969) 1292–1299. [DOI] [PMID: 4916924] |
| 4. |
Wright, M., Buttin, G. and Hurwitz, J. The isolation and characterization from Escherichia coli of an adenosine triphosphate-dependent deoxyribonuclease directed by rec B, C genes. J. Biol. Chem. 246 (1971) 6543–6555. [PMID: 4332130] |
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| [EC 3.1.11.5 created 1978] |
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