| EC |
3.1.2.31 |
| Accepted name: |
dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase |
| Reaction: |
dihydromonacolin L-[lovastatin nonaketide synthase] + H2O = holo-[lovastatin nonaketide synthase] + dihydromonacolin L acid |
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For diagram of lovastatin biosynthesis, click here |
| Glossary: |
dihydromonacolin L acid = (3R,5R)-7-[(1S,2S,4aR,6R,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate |
| Other name(s): |
LovG |
| Systematic name: |
dihydromonacolin L-[lovastatin nonaketide synthase] hydrolase |
| Comments: |
Dihydromonacolin L acid is synthesized while bound to an acyl-carrier protein domain of the lovastatin nonaketide synthase (EC 2.3.1.161). Since that enzyme lacks a thioesterase domain, release of the dihydromonacolin L acid moiety from the polyketide synthase requires this dedicated enzyme. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Xu, W., Chooi, Y.H., Choi, J.W., Li, S., Vederas, J.C., Da Silva, N.A. and Tang, Y. LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis. Angew. Chem. Int. Ed. Engl. 52 (2013) 6472–6475. [DOI] [PMID: 23653178] |
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| [EC 3.1.2.31 created 2015] |
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