ExplorEnz: EC 3.1.2.35

Your query returned 1 entry. Printable version

3.1.2.35

Accepted name:

6-hydroxymusizin-2-carbonyl-[acyl-carrier protein] thioesterase

Reaction:

6-hydroxymusizin-2-carbonyl-[acyl-carrier protein] + H₂O = 6-hydroxymusizin + CO₂ + [acyl-carrier protein] (overall reaction)
(1a) 6-hydroxymusizin-2-carbonyl-[acyl-carrier protein] + H₂O = 6-hydroxymusizin carboxylate + [acyl-carrier protein]
(1b) 6-hydroxymusizin carboxylate = 6-hydroxymusizin + CO₂ (spontaneous)

Glossary:

6-hydroxymusizin = (1,6,8-trihydroxynaphthalen-2-yl)ethan-1-one

Systematic name:

6-hydroxymusizin-2-carbonyl-[acyl-carrier protein] hydrolase

Comments:

Found in the mushrooms Calonarius odorifer and Calonarius rufo-olivaceus and the mould Chrysosporium merdarium.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Thiele, W., Obermaier, S. and Muller, M. A fasciclin protein Is essential for laccase-mediated selective phenol coupling in sporandol biosynthesis. ACS Chem. Biol. 15 (2020) 844–848. [DOI] [PMID: 32227858]
2.	Lohr, N.A., Eisen, F., Thiele, W., Platz, L., Motter, J., Huttel, W., Gressler, M., Muller, M. and Hoffmeister, D. Unprecedented mushroom polyketide synthases produce the universal anthraquinone precursor. Angew. Chem. Int. Ed. Engl. 61:e202116142 (2022). [DOI] [PMID: 35218274]
3.	Lohr, N.A., Urban, M.C., Eisen, F., Platz, L., Huttel, W., Gressler, M., Muller, M. and Hoffmeister, D. The ketosynthase domain controls chain length in mushroom oligocyclic polyketide synthases. Chembiochem 24:e202200649 (2023). [DOI] [PMID: 36507600]
4.	Lohr, N.A., Rakhmanov, M., Wurlitzer, J.M., Lackner, G., Gressler, M. and Hoffmeister, D. Basidiomycete non-reducing polyketide synthases function independently of SAT domains. Fungal Biol Biotechnol 10:17 (2023). [DOI] [PMID: 37542286]

[EC 3.1.2.35 created 2025]