EC 3.1.21.4     
Accepted name: type II site-specific deoxyribonuclease
Reaction: Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5′-phosphates
Other name(s): type II restriction enzyme
Comments: This is a large group of enzymes which, together with those now listed as EC 3.1.21.3 (type 1 site-specific deoxyribonuclease) and EC 3.1.21.5.
References:
1.  Roberts, R.J. Restriction enzymes and their isoschizomers. Nucleic Acids Res. 18 (1990) 2331–2365. [PMID: 2159140]
[EC 3.1.21.4 created 1984 from EC 3.1.23 and EC 3.1.24]