| EC |
3.1.21.6 |
| Accepted name: |
CC-preferring endodeoxyribonuclease |
| Reaction: |
endonucleolytic cleavage to give 5′-phosphooligonucleotide end-products, with a preference for cleavage within the sequence CC |
| Other name(s): |
Streptomyces glaucescens exocytoplasmic dodeoxyribonuclease |
| Comments: |
Prefers CC sites in double-stranded circular and linear DNA. Greater affinity for double-stranded than single-stranded DNA. Produces nicks, generating double-stranded fragments with 5′- and/or 3′-protruding single-stranded tails. Requires magnesium ions for activity. The endonuclease from Chlorella-like green algae infected with NYs-1 virus 4[1] may be the same enzyme. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37211-67-9 |
| References: |
| 1. |
Xia, Y.N., Morgan, R., Schildkraut, I., Van Etten, J.L. A site-specific single-strand endonuclease activity induced by NYs-1 virus-infection of a Chlorella-like green-alga. Nucleic Acids Res. 16 (1988) 9477–9487. [DOI] [PMID: 3186439] |
| 2. |
Aparicio, J.F., Lopez-Otin, C., Cal, S., Sanchez, J. A Streptomyces glaucescens endodeoxyribonuclease which shows a strong preference for CC dinucleotide. Eur. J. Biochem. 205 (1992) 695–699. [DOI] [PMID: 1533367] |
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| [EC 3.1.21.6 created 1999] |
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