ExplorEnz: EC 3.1.3.113

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3.1.3.113

Accepted name:

phospholipid phosphatase

Reaction:

a phospholipid + H₂O = a lipid + phosphate

Other name(s):

lipid phosphate phosphatase; type 2 phosphatidic acid phosphatase; PAP2; PLPP1 (gene name); PLPP2 (gene name); PLPP3 (gene name); PLPP4 (gene name)

Systematic name:

phospholipid phosphohydrolase

Comments:

The enzyme is a Mg²⁺-independent phosphatase that catalyses the dephosphorylation of a broad spectrum of glycerolipid and sphingolipid phosphate esters, including phosphatidate, lysophosphatidate, diacylglycerol pyrophosphate, sphingosine 1-phosphate, and ceramide 1-phosphate. cf. EC 3.1.3.4, phosphatidate phosphatase, EC 3.1.3.106, 2-lysophosphatidate phosphatase, EC 3.1.3.114, sphingoid-base-1-phosphate phosphatase, and EC 3.1.3.115, ceramide-1-phosphate phosphatase.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Kai, M., Wada, I., Imai Si, Sakane, F. and Kanoh, H. Cloning and characterization of two human isozymes of Mg²⁺-independent phosphatidic acid phosphatase. J. Biol. Chem. 272 (1997) 24572–24578. [DOI] [PMID: 9305923]
2.	Hooks, S.B., Ragan, S.P. and Lynch, K.R. Identification of a novel human phosphatidic acid phosphatase type 2 isoform. FEBS Lett. 427 (1998) 188–192. [DOI] [PMID: 9607309]
3.	Roberts, R., Sciorra, V.A. and Morris, A.J. Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform. J. Biol. Chem. 273 (1998) 22059–22067. [DOI] [PMID: 9705349]
4.	Waggoner, D.W., Xu, J., Singh, I., Jasinska, R., Zhang, Q.X. and Brindley, D.N. Structural organization of mammalian lipid phosphate phosphatases: implications for signal transduction. Biochim. Biophys Acta 1439 (1999) 299–316. [DOI] [PMID: 10425403]
5.	Roberts, R.Z. and Morris, A.J. Role of phosphatidic acid phosphatase 2a in uptake of extracellular lipid phosphate mediators. Biochim. Biophys Acta 1487 (2000) 33–49. [DOI] [PMID: 10962286]
6.	Zhao, Y., Kalari, S.K., Usatyuk, P.V., Gorshkova, I., He, D., Watkins, T., Brindley, D.N., Sun, C., Bittman, R., Garcia, J.G., Berdyshev, E.V. and Natarajan, V. Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1. J. Biol. Chem. 282 (2007) 14165–14177. [DOI] [PMID: 17379599]
7.	Tang, X., Benesch, M.G. and Brindley, D.N. Lipid phosphate phosphatases and their roles in mammalian physiology and pathology. J. Lipid Res. 56 (2015) 2048–2060. [DOI] [PMID: 25814022]

[EC 3.1.3.113 created 2026]