ExplorEnz: EC 3.1.3.114

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3.1.3.114

Accepted name:

sphingoid-base-1-phosphate phosphatase

Reaction:

a sphingoid base 1-phosphate + H₂O = a sphingoid base + phosphate

Other name(s):

S1P phosphatase; sphingosine-1-phosphate phosphatase; long-chain base-1-phosphate phosphatase; dihydrosphingosine-1-phosphate phosphatase; LCB3 (gene name); YSR3 (gene name); SGPP1 (gene name); SGPP2 (gene name)

Systematic name:

sphingoid base 1-phosphate phosphohydrolase

Comments:

The enzyme specifically dephosphorylates long-chain sphingoid base phosphates such as sphingosine 1-phosphate, sphinganine 1-phosphate, and phytosphingosine 1-phosphate. It does not act on ceramide 1-phosphate, lysophosphatidic acids, or phosphatidic acids. cf. EC 3.1.3.4, phosphatidate phosphatase, EC 3.1.3.106, 2-lysophosphatidate phosphatase, and EC 3.1.3.113, phospholipid phosphatase.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Mandala, S.M., Thornton, R., Tu, Z., Kurtz, M.B., Nickels, J., Broach, J., Menzeleev, R. and Spiegel, S. Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response. Proc. Natl. Acad. Sci. USA 95 (1998) 150–155. [DOI] [PMID: 9419344]
2.	Mao, C., Saba, J.D. and Obeid, L.M. The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses. Biochem. J. 342 Pt 3 (1999) 667–675. [DOI] [PMID: 10477278]
3.	Ogawa, C., Kihara, A., Gokoh, M. and Igarashi, Y. Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2. J. Biol. Chem. 278 (2003) 1268–1272. [DOI] [PMID: 12411432]
4.	Giussani, P., Maceyka, M., Le Stunff, H., Mikami, A., Lepine, S., Wang, E., Kelly, S., Merrill, A.H., Jr., Milstien, S. and Spiegel, S. Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. Mol. Cell Biol. 26 (2006) 5055–5069. [DOI] [PMID: 16782891]

[EC 3.1.3.114 created 2026]