ExplorEnz: EC 3.1.3.115

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3.1.3.115

Accepted name:

ceramide-1-phosphate phosphatase

Reaction:

a ceramide 1-phosphate + H₂O = a ceramide + phosphate

Other name(s):

C₁PP; C₁P phosphatase

Systematic name:

ceramide-1-phosphate phosphohydrolase

Comments:

Ceramide 1-phosphate, produced by EC 2.7.1.138, ceramide kinase, is dephosphorylated in mammalian tissue. EC 3.1.3.113, phospholipid phosphatase, has been shown to catalyse this activity in vitro.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Shinghal, R., Scheller, R.H. and Bajjalieh, S.M. Ceramide 1-phosphate phosphatase activity in brain. J. Neurochem. 61 (1993) 2279–2285. [DOI] [PMID: 8245978]
2.	Boudker, O. and Futerman, A.H. Detection and characterization of ceramide-1-phosphate phosphatase activity in rat liver plasma membrane. J. Biol. Chem. 268 (1993) 22150–22155. [DOI] [PMID: 8408075]
3.	Waggoner, D.W., Gomez-Munoz, A., Dewald, J. and Brindley, D.N. Phosphatidate phosphohydrolase catalyzes the hydrolysis of ceramide 1-phosphate, lysophosphatidate, and sphingosine 1-phosphate. J. Biol. Chem. 271 (1996) 16506–16509. [DOI] [PMID: 8663293]
4.	Roberts, R., Sciorra, V.A. and Morris, A.J. Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform. J. Biol. Chem. 273 (1998) 22059–22067. [DOI] [PMID: 9705349]
5.	Brindley, D.N., Xu, J., Jasinska, R. and Waggoner, D.W. Analysis of ceramide 1-phosphate and sphingosine-1-phosphate phosphatase activities. Methods Enzymol. 311 (2000) 233–244. [DOI] [PMID: 10563330]

[EC 3.1.3.115 created 2026]