ExplorEnz: EC 3.1.3.4

3.1.3.4

Accepted name:

phosphatidate phosphatase

Reaction:

a 1,2-diacylglycerol 3-phosphate + H₂O = a 1,2-diacyl-sn-glycerol + phosphate

Glossary:

a 1,2-diacylglycerol 3-phosphate = a 3-sn-phosphatidate
a 1,2-diacyl-sn-glycerol = diacylglycerol = DAG

Other name(s):

phosphatic acid phosphatase; acid phosphatidyl phosphatase; phosphatic acid phosphohydrolase; PAP; Lipin

Systematic name:

diacylglycerol-3-phosphate phosphohydrolase

Comments:

This enzyme catalyses the Mg²⁺-dependent dephosphorylation of a 1,2-diacylglycerol-3-phosphate, yielding a 1,2-diacyl-sn-glycerol (DAG), the substrate for de novo lipid synthesis via the Kennedy pathway and for the synthesis of triacylglycerol. In lipid signalling, the enzyme generates a pool of DAG to be used for protein kinase C activation. The mammalian enzymes are known as lipins.

References:

1.	Smith, S.W., Weiss, S.B. and Kennedy, E.P. The enzymatic dephosphorylation of phosphatidic acids. J. Biol. Chem. 228 (1957) 915–922. [PMID: 13475370]
2.	Carman, G.M. and Han, G.S. Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis. J. Biol. Chem. 284 (2009) 2593–2597. [PMID: 18812320]

[EC 3.1.3.4 created 1961, modified 2010]