ExplorEnz: EC 3.1.3.64

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3.1.3.64

Accepted name:

phosphatidylinositol-3-phosphatase

Reaction:

1-phosphatidyl-1D-myo-inositol 3-phosphate + H₂O = 1-phosphatidyl-1D-myo-inositol + phosphate

For diagram of 1-phosphatidyl-myo-inositol metabolism, click here

Glossary:

inositol 1-phosphate = Ins-1-P
inositol 1,3-bisphosphate = Ins(1,3)P₂
1-phosphatidyl-1D-myo-inositol = PtdIns
1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P

Other name(s):

inositol-1,3-bisphosphate 3-phosphatase; inositol 1,3-bisphosphate phosphatase; inositol-polyphosphate 3-phosphatase; D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase; phosphatidyl-3-phosphate 3-phosphohydrolase

Systematic name:

1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase

Comments:

This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3)P₂ to Ins-1-P.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 124248-47-1

References:

1.	Lips, D.L. and Majerus, P.W. The discovery of a 3-phosphomonoesterase that hydrolyzes phosphatidylinositol 3-phosphate in NIH 3T3 cells. J. Biol. Chem. 264 (1989) 19911–19915. [PMID: 2555336]
2.	Caldwell, K.K., Lips, D.L., Bansal, V.S. and Majerus, P.W. Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. J. Biol. Chem. 266 (1991) 18378–18386. [PMID: 1655747]

[EC 3.1.3.64 created 1992, [EC 3.1.3.65 created 1992, incorporated 2002], modified 2002]]