ExplorEnz: EC 3.1.3.66

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3.1.3.66

Accepted name:

phosphatidylinositol-3,4-bisphosphate 4-phosphatase

Reaction:

1-phosphatidyl-myo-inositol 3,4-bisphosphate + H₂O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate

For diagram of 1-phosphatidyl-myo-inositol metabolism, click here

Glossary:

inositol 3-phosphate = Ins-3-P
inositol 1,3-bisphosphate = Ins(1,3)P₂
inositol 3,4-bisphosphate = Ins(3,4)P₂
inositol 1,3,4-trisphosphate = Ins(1,3,4)P₃
1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P
1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P

Other name(s):

inositol-3,4-bisphosphate 4-phosphatase; D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase; phosphoinositide 4-phosphatase; inositol polyphosphate 4-phosphatase; inositol polyphosphate 4-phosphatase type II

Systematic name:

1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase

Comments:

Mg²⁺-independent. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4)P₃ to Ins(1,3)P₂. It also converts Ins(3,4)P₂ into Ins-3-P.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 123644-80-4

References:

1.	Howell, S., Barnaby, R.J., Rowe, T., Ragan, C.I. and Gee, N.S. Evidence for at least four different inositol bisphosphatases in bovine brain. Eur. J. Biochem. 183 (1989) 169–172. [DOI] [PMID: 2546770]
2.	Norris, F.A., Auethavekiat, V. and Majerus, P.W. The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase. J. Biol. Chem. 270 (1995) 16128–16133. [DOI] [PMID: 7608176]
3.	Norris, F.A., Atkins, R.C. and Majerus, P.W. The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family. J. Biol. Chem. 272 (1997) 23859–23864. [DOI] [PMID: 9295334]

[EC 3.1.3.66 created 1992, modified 2002]