| EC |
3.1.3.71 |
| Accepted name: |
2-phosphosulfolactate phosphatase |
| Reaction: |
(2R)-2-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate |
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For diagram of coenzyme-M biosynthesis, click here |
| Other name(s): |
(2R)-phosphosulfolactate phosphohydrolase; ComB phosphatase |
| Systematic name: |
(R)-2-phospho-3-sulfolactate phosphohydrolase |
| Comments: |
Requires Mg2+. The enzyme from Methanococcus jannaschii acts on both stereoisoimers of the substrate and also hydrolyses a number of phosphate monoesters of (S)-2-hydroxycarboxylic acids, including 2-phosphomalate, 2-phospholactate and 2-phosphoglycolate. This enzyme can also hydrolyse phosphate monoesters of (R)-2-hydroxycarboxylic acids such as (S)-2-phospho-3-sulfolactate and (R)-2-phosphomalate, which, presumably, bind to the enzyme in opposite orientations. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 409095-18-7 |
| References: |
| 1. |
Graham, D.E., Graupner, M., Xu, H. and White, R.H. Identification of coenzyme M biosynthetic 2-phosphosulfolactate phosphatase. Eur. J. Biochem. 268 (2001) 5176–5188. [DOI] [PMID: 11589710] |
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| [EC 3.1.3.71 created 2002] |
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