ExplorEnz: EC 3.1.3.73

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3.1.3.73

Accepted name:

adenosylcobalamin/α-ribazole phosphatase

Reaction:

(1) adenosylcobalamin 5′-phosphate + H₂O = adenosylcobalamin + phosphate
(2) α-ribazole 5′-phosphate + H₂O = α-ribazole + phosphate

For diagram of corrin biosynthesis (part 8), click here

Other name(s):

CobC; adenosylcobalamin phosphatase; α-ribazole phosphatase

Systematic name:

adenosylcobalamin/α-ribazole-5′-phosphate phosphohydrolase

Comments:

This enzyme catalyses the last step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, characterized in Salmonella enterica [3].It also participates in a salvage pathway that recycles cobinamide into adenosylcobalamin [1].

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 251991-06-7

References:

1.	O'Toole, G.A., Trzebiatowski, J.R. and Escalante-Semerena, J.C. The cobC gene of Salmonella typhimurium codes for a novel phosphatase involved in the assembly of the nucleotide loop of cobalamin. J. Biol. Chem. 269 (1994) 26503–26511. [PMID: 7929373]
2.	Warren, M.J., Raux, E., Schubert, H.L. and Escalante-Semerena, J.C. The biosynthesis of adenosylcobalamin (vitamin B₁₂). Nat. Prod. Rep. 19 (2002) 390–412. [PMID: 12195810]
3.	Zayas, C.L. and Escalante-Semerena, J.C. Reassessment of the late steps of coenzyme B₁₂ synthesis in Salmonella enterica: evidence that dephosphorylation of adenosylcobalamin-5′-phosphate by the CobC phosphatase is the last step of the pathway. J. Bacteriol. 189 (2007) 2210–2218. [DOI] [PMID: 17209023]

[EC 3.1.3.73 created 2004, modified 2011]