| EC |
3.1.3.80 |
| Accepted name: |
2,3-bisphosphoglycerate 3-phosphatase |
| Reaction: |
2,3-bisphospho-D-glycerate + H2O = 2-phospho-D-glycerate + phosphate |
| Other name(s): |
MIPP1; 2,3-BPG 3-phosphatase |
| Systematic name: |
2,3-bisphospho-D-glycerate 3-phosphohydrolase |
| Comments: |
This reaction is a shortcut in the Rapoport-Luebering shunt. It bypasses the reactions of EC 5.4.2.11/EC 5.4.2.12 [phosphoglycerate mutases (2,3-diphosphoglycerate-dependent and independent)] and directly forms 2-phospho-D-glycerate by removing the 3-phospho-group of 2,3-diphospho-D-glycerate [1]. The MIPP1 protein also catalyses the reaction of EC 3.1.3.62 (multiple inositol-polyphosphate phosphatase). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Cho, J., King, J.S., Qian, X., Harwood, A.J. and Shears, S.B. Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt. Proc. Natl. Acad. Sci. USA 105 (2008) 5998–6003. [DOI] [PMID: 18413611] |
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| [EC 3.1.3.80 created 2010] |
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