EC |
3.1.3.83 |
Accepted name: |
D-glycero-α-D-manno-heptose 1,7-bisphosphate 7-phosphatase |
Reaction: |
D-glycero-α-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-α-D-manno-heptose 1-phosphate + phosphate
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Other name(s): |
gmhB (gene name) |
Systematic name: |
D-glycero-α-D-manno-heptose 1,7-bisphosphate 7-phosphohydrolase |
Comments: |
The enzyme is involved in biosynthesis of GDP-D-glycero-α-D-manno-heptose, which is required for assembly of S-layer glycoprotein in some Gram-positive bacteria. The in vitro catalytic efficiency of the enzyme from Bacteroides thetaiotaomicron is 6-fold higher with the α-anomer than with the β-anomer [1]. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Wang, L., Huang, H., Nguyen, H.H., Allen, K.N., Mariano, P.S. and Dunaway-Mariano, D. Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB). Biochemistry 49 (2010) 1072–1081. [DOI] [PMID: 20050615] |
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[EC 3.1.3.83 created 2010] |
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