| EC |
3.1.3.9 |
| Accepted name: |
glucose-6-phosphatase |
| Reaction: |
D-glucose 6-phosphate + H2O = D-glucose + phosphate |
| Other name(s): |
glucose 6-phosphate phosphatase |
| Systematic name: |
D-glucose-6-phosphate phosphohydrolase |
| Comments: |
Wide distribution in animal tissues. Also catalyses potent transphosphorylations from carbamoyl phosphate, hexose phosphates, diphosphate, phosphoenolpyruvate and nucleoside di- and triphosphates, to D-glucose, D-mannose, 3-methyl-D-glucose or 2-deoxy-D-glucose [cf. EC 2.7.1.62 (phosphoramidate—hexose phosphotransferase), EC 2.7.1.79 (diphosphate—glycerol phosphotransferase) and EC 3.9.1.1 (phosphoamidase)]. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9001-39-2 |
| References: |
| 1. |
Anchors, J.M. and Karnovsky, N.L. Purification of cerebral glucose-6-phosphatase. An enzyme involved in sleep. J. Biol. Chem. 250 (1975) 6408–6416. [PMID: 169241] |
| 2. |
Colilla, W., Jorgenson, R.A. and Nordlie, R.C. Mammalian carbamyl phosphate : glucose phosphotransferase and glucose-6-phosphate phosphohydrolase: extended tissue distribution. Biochim. Biophys. Acta 377 (1975) 117. [DOI] [PMID: 164220] |
| 3. |
Nordlie, R.C. Glucose-6-phosphatase, hydrolytic and synthetic activities. In: Boyer, P.D. (Ed.), The Enzymes, 3rd edn, vol. 4, Academic Press, New York, 1971, pp. 543–610. |
| 4. |
Nordlie, R.C. Metabolic regulation by multifunctional glucose-6-phosphatase. Curr. Top. Cell. Regul. 8 (1974) 33. [PMID: 4370737] |
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| [EC 3.1.3.9 created 1961] |
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