ExplorEnz: EC 3.1.3.91

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3.1.3.91

Accepted name:

7-methylguanosine nucleotidase

Reaction:

(1) N⁷-methyl-GMP + H₂O = N⁷-methyl-guanosine + phosphate
(2) CMP + H₂O = cytidine + phosphate

Other name(s):

cytosolic nucleotidase III-like; cNIII-like; N⁷-methylguanylate 5′-phosphatase

Systematic name:

N⁷-methyl-GMP phosphohydrolase

Comments:

The enzyme also has low activity with N⁷-methyl-GDP, producing N⁷-methyl-GMP. Does not accept AMP or GMP, and has low activity with UMP.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Buschmann, J., Moritz, B., Jeske, M., Lilie, H., Schierhorn, A. and Wahle, E. Identification of Drosophila and human 7-methyl GMP-specific nucleotidases. J. Biol. Chem. 288 (2013) 2441–2451. [DOI] [PMID: 23223233]

[EC 3.1.3.91 created 2013]