| EC |
3.1.4.1 |
| Accepted name: |
phosphodiesterase I |
| Reaction: |
Hydrolytically removes 5′-nucleotides successively from the 3′-hydroxy termini of 3′-hydroxy-terminated oligonucleotides |
| Other name(s): |
5′-exonuclease; 5′-phosphodiesterase; 5′-nucleotide phosphodiesterase; oligonucleate 5′-nucleotidohydrolase; 5′ nucleotide phosphodiesterase/alkaline phosphodiesterase I; 5′-NPDase; 5′-PDase; 5′-PDE; 5’NPDE; alkaline phosphodiesterase; nucleotide pyrophosphatase/phosphodiesterase I; orthophosphoric diester phosphohydrolase; PDE I; phosphodiesterase (ambiguous); exonuclease I |
| Systematic name: |
oligonucleotide 5′-nucleotidohydrolase |
| Comments: |
Hydrolyses both ribonucleotides and deoxyribonucleotides. Has low activity towards polynucleotides. A 3′-phosphate terminus on the substrate inhibits hydrolysis. |
| Links to other databases: |
BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9025-82-5 |
| References: |
| 1. |
Khorana, G.H. Phosphodiesterases. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Ed.), The Enzymes, 2nd edn, vol. 5, Academic Press, New York, 1961, pp. 79–94. |
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| [EC 3.1.4.1 created 1961] |
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