| EC |
3.1.4.12 |
| Accepted name: |
sphingomyelin phosphodiesterase |
| Reaction: |
a sphingomyelin + H2O = a ceramide + phosphocholine |
| Glossary: |
a ceramide = an N-acylsphingosine |
| Other name(s): |
neutral sphingomyelinase |
| Systematic name: |
sphingomyelin cholinephosphohydrolase |
| Comments: |
Has very little activity on phosphatidylcholine. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9031-54-3 |
| References: |
| 1. |
Barnholz, Y., Roitman, A. and Gatt, S. Enzymatic hydrolysis of sphingolipids. II. Hydrolysis of sphingomyelin by an enzyme from rat brain. J. Biol. Chem. 241 (1966) 3731–3737. [PMID: 5916388] |
| 2. |
Chatterjee, S. and Ghosh, N. Neutral sphingomyelinase from human urine. Purification and preparation of monospecific antibodies. J. Biol. Chem. 264 (1989) 12554–12561. [PMID: 2545711] |
| 3. |
Heller, M. and Shapiro, B. Enzymic hydrolysis of sphingomyelin by rat liver. Biochem. J. 98 (1966) 763–769. [PMID: 5911524] |
| 4. |
Kanfer, J.N., Young, O.M., Shapiro, D. and Brady, R.O. The metabolism of sphingomyelin. I. Purification and properties of a sphingomyelin-cleaving enzyme from rat liver tissue. J. Biol. Chem. 241 (1966) 1081–1084. [PMID: 5933867] |
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| [EC 3.1.4.12 created 1972] |
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