ExplorEnz: EC 3.1.4.55

Your query returned 1 entry. Printable version

3.1.4.55

Accepted name:

phosphoribosyl 1,2-cyclic phosphate phosphodiesterase

Reaction:

5-phospho-α-D-ribose 1,2-cyclic phosphate + H₂O = α-D-ribose 1,5-bisphosphate

For diagram of phosphonate metabolism, click here

Other name(s):

phnP (gene name)

Systematic name:

5-phospho-α-D-ribose 1,2-cyclic phosphate 2-phosphohydrolase (α-D-ribose 1,5-bisphosphate-forming)

Comments:

Binds Mn²⁺ and Zn²⁺. Isolated from the bacterium Escherichia coli, where it participates in the degradation of methylphosphonate.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Podzelinska, K., He, S.M., Wathier, M., Yakunin, A., Proudfoot, M., Hove-Jensen, B., Zechel, D.L. and Jia, Z. Structure of PhnP, a phosphodiesterase of the carbon-phosphorus lyase pathway for phosphonate degradation. J. Biol. Chem. 284 (2009) 17216–17226. [DOI] [PMID: 19366688]
2.	Hove-Jensen, B., McSorley, F.R. and Zechel, D.L. Physiological role of phnP-specified phosphoribosyl cyclic phosphodiesterase in catabolism of organophosphonic acids by the carbon-phosphorus lyase pathway. J. Am. Chem. Soc. 133 (2011) 3617–3624. [DOI] [PMID: 21341651]
3.	He, S.M., Wathier, M., Podzelinska, K., Wong, M., McSorley, F.R., Asfaw, A., Hove-Jensen, B., Jia, Z. and Zechel, D.L. Structure and mechanism of PhnP, a phosphodiesterase of the carbon-phosphorus lyase pathway. Biochemistry 50 (2011) 8603–8615. [DOI] [PMID: 21830807]

[EC 3.1.4.55 created 2013]