EC |
3.1.4.61 |
Accepted name: |
cyclic 2,3-diphosphoglycerate hydrolase |
Reaction: |
cyclic 2,3-bisphosphoglycerate + H2O = 2,3-diphosphoglycerate |
Systematic name: |
cyclic 2,3-diphosphoglycerate phosphohydrolyase |
Comments: |
The enzyme degrades cyclic 2,3-bisphosphoglycerate, a thermoprotectant that is produced by certain archaeal genera. Two different enzymes that catalyse this activity, one soluble and one membrane-bound, have been characterized from the archaeon Methanothermobacter thermautotrophicus. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Sastry, M.V., Robertson, D.E., Moynihan, J.A. and Roberts, M.F. Enzymatic degradation of cyclic 2,3-diphosphoglycerate to 2,3-diphosphoglycerate in Methanobacterium thermoautotrophicum. Biochemistry 31 (1992) 2926–2935. [DOI] [PMID: 1550819] |
2. |
Alebeek G, J.WM., Kreuwels, M.JJ., Keltjens, J.T. and Vogels, G.D. Methanobacterium thermoautotrophicum (strain ΔH) contains a membrane-bound cyclic 2,3-diphosphoglycerate hydrolase. Arch. Microbiol. 161 (1994) 514–520. [DOI] |
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[EC 3.1.4.61 created 2021] |
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