The Enzyme Database

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Accepted name: aryldialkylphosphatase
Reaction: an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol
Other name(s): organophosphate hydrolase; paraoxonase; A-esterase; aryltriphosphatase; organophosphate esterase; esterase B1; esterase E4; paraoxon esterase; pirimiphos-methyloxon esterase; OPA anhydrase (ambiguous); organophosphorus hydrolase; phosphotriesterase; paraoxon hydrolase; OPH; organophosphorus acid anhydrase
Systematic name: aryltriphosphate dialkylphosphohydrolase
Comments: Acts on organophosphorus compounds (such as paraoxon) including esters of phosphonic and phosphinic acids. Inhibited by chelating agents; requires divalent cations for activity. Previously regarded as identical with EC arylesterase.
Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 117698-12-1
1.  Aldridge, W.N. Serum esterases. I. Two types of esterase (A and B) hydrolysing p-nitrophenyl acetate, propionate and butyrate and a method for their determination. Biochem. J. 53 (1953) 110–117. [PMID: 13032041]
2.  Bosmann, H.B. Membrane marker enzymes. Characterization of an arylesterase of guinea pig cerebral cortex utilizing p-nitrophenyl acetate as substrate. Biochim. Biophys. Acta 276 (1972) 180–191. [DOI] [PMID: 5047702]
3.  Mackness, M.I., Thompson, H.M., Hardy, A.R. and Walker, C.H. Distinction between 'A′-esterases and arylesterases. Implications for esterase classification. Biochem. J. 245 (1987) 293–296. [PMID: 2822017]
4.  Main, A.R. The differentiation of the A-type esterases in sheep serum. Biochem. J. 75 (1960) 188–195. [PMID: 14420012]
5.  Reiner, E., Aldridge, W.N. and Hoskin, C.G. (Ed.), Enzymes Hydrolysing Organophosphorus Compounds, Ellis Horwood, Chichester, UK, 1989.
[EC created 1989]

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