| EC |
3.1.8.1 |
| Accepted name: |
aryldialkylphosphatase |
| Reaction: |
an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol |
| Other name(s): |
organophosphate hydrolase; paraoxonase; A-esterase; aryltriphosphatase; organophosphate esterase; esterase B1; esterase E4; paraoxon esterase; pirimiphos-methyloxon esterase; OPA anhydrase (ambiguous); organophosphorus hydrolase; phosphotriesterase; paraoxon hydrolase; OPH; organophosphorus acid anhydrase |
| Systematic name: |
aryltriphosphate dialkylphosphohydrolase |
| Comments: |
Acts on organophosphorus compounds (such as paraoxon) including esters of phosphonic and phosphinic acids. Inhibited by chelating agents; requires divalent cations for activity. Previously regarded as identical with EC 3.1.1.2 arylesterase. |
| Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 117698-12-1 |
| References: |
| 1. |
Aldridge, W.N. Serum esterases. I. Two types of esterase (A and B) hydrolysing p-nitrophenyl acetate, propionate and butyrate and a method for their determination. Biochem. J. 53 (1953) 110–117. [PMID: 13032041] |
| 2. |
Bosmann, H.B. Membrane marker enzymes. Characterization of an arylesterase of guinea pig cerebral cortex utilizing p-nitrophenyl acetate as substrate. Biochim. Biophys. Acta 276 (1972) 180–191. [DOI] [PMID: 5047702] |
| 3. |
Mackness, M.I., Thompson, H.M., Hardy, A.R. and Walker, C.H. Distinction between 'A′-esterases and arylesterases. Implications for esterase classification. Biochem. J. 245 (1987) 293–296. [PMID: 2822017] |
| 4. |
Main, A.R. The differentiation of the A-type esterases in sheep serum. Biochem. J. 75 (1960) 188–195. [PMID: 14420012] |
| 5. |
Reiner, E., Aldridge, W.N. and Hoskin, C.G. (Ed.), Enzymes Hydrolysing Organophosphorus Compounds, Ellis Horwood, Chichester, UK, 1989. |
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| [EC 3.1.8.1 created 1989] |
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