| EC |
3.2.1.143 |
| Accepted name: |
poly(ADP-ribose) glycohydrolase |
| Reaction: |
hydrolyses poly(ADP-D-ribose) at glycosidic (1′′-2′) linkage of ribose-ribose bond to produce free ADP-D-ribose |
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For diagram of reaction, click here |
| Glossary: |
ADP-D-ribose = adenosine 5′-(5-deoxy-D-ribofuranos-5-yl diphosphate) |
| Comments: |
Specific to (1′′-2′) linkage of ribose-ribose bond of poly(ADP-D-ribose). |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9068-16-0 |
| References: |
| 1. |
Miwa, M. and Sugimura, T. Splitting of the ribose-ribose linkage of poly(adenosine diphosphate-ribose) by a calf thymus extract. J. Biol. Chem. 246 (1971) 6362–6364. [PMID: 4331388] |
| 2. |
Lin, W., Ame, J.C., Aboul-Ela, N., Jacobson, E.L. and Jacobson, M.K. Isolation and characterization of the cDNA encoding bovine poly(ADP-ribose) glycohydrolase. J. Biol. Chem. 272 (1997) 11895–11901. [DOI] [PMID: 9115250] |
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| [EC 3.2.1.143 created 2000] |
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