| EC |
3.2.1.20 |
| Accepted name: |
α-glucosidase |
| Reaction: |
Hydrolysis of terminal (1→4)-linked α-D-glucose residues from the non-reducing ends of oligosaccharides with release of α-D-glucose |
| Other name(s): |
maltase; glucoinvertase; glucosidosucrase; maltase-glucoamylase; α-glucopyranosidase; glucosidoinvertase; α-D-glucosidase; α-glucoside hydrolase; α-1,4-glucosidase; α-D-glucoside glucohydrolase |
| Systematic name: |
4-α-D-glucoside exo α-(1,4)-glucohydrolase (non-reducing end, configuration-retaining) |
| Comments: |
This single entry covers a group of enzymes whose specificity is directed mainly towards the exohydrolysis of (1→4)-α-glucosidic linkages, and that hydrolyse oligosaccharides rapidly, relative to polysaccharide, which are hydrolysed relatively slowly, or not at all. The intestinal enzyme also hydrolyses polysaccharides, catalysing a reaction similar to EC 3.2.1.3, glucan 1,4-α-glucosidase, but releasing α- rather than β-glucose residues. The enzyme can also hydrolyse (1→6)-α-D-glucose links, but more slowly. |
| Links to other databases: |
BRENDA, EXPASY, Gene, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9001-42-7 |
| References: |
| 1. |
Bruni, C.B., Sica, V., Auricchio, F. and Covelli, I. Further kinetic and structural characterization of the lysosomal α-D-glucoside glucohydrolase from cattle liver. Biochim. Biophys. Acta 212 (1970) 470–477. [DOI] [PMID: 5466143] |
| 2. |
Flanagan, P.R. and Forstner, G.G. Purification of rat intestinal maltase/glucoamylase and its anomalous dissociation either by heat or by low pH. Biochem. J. 173 (1978) 553–563. [PMID: 29602] |
| 3. |
Larner, J. Other glucosidases. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Ed.), The Enzymes, 2nd edn, vol. 4, Academic Press, New York, 1960, pp. 369–378. |
| 4. |
Sivikami, S. and Radhakrishnan, A.N. Purification of rabbit intestinal glucoamylase by affinity chromatography on Sephadex G-200. Indian J. Biochem. Biophys. 10 (1973) 283–284. [PMID: 4792946] |
| 5. |
Sørensen, S.H., Norén, O., Sjöström, H. and Danielsen, E.M. Amphiphilic pig intestinal microvillus maltase/glucoamylase. Structure and specificity. Eur. J. Biochem. 126 (1982) 559–568. [DOI] [PMID: 6814909] |
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| [EC 3.2.1.20 created 1961] |
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