ExplorEnz: EC 3.2.1.218

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3.2.1.218

Accepted name:

α-3′-ketoglucosidase

Reaction:

3′-dehydrosucrose + H₂O = 3-dehydro-D-glucopyranose + D-fructofuranose

Other name(s):

3′-keto-α-D-gluco-disaccharide hydrolase; α-3-ketoglucosidase (incorrect); 3-keto-glucoside hydrolase

Systematic name:

3′-dehydrosucrose 3′-dehydroglucohydrolase

Comments:

The enzyme, originally characterized from the bacterium Agrobacterium tumefaciens, is specific for disaccharides that contain a 3-dehydro-α-D-glucose at the non-reducing end such as 3′-dehydrosucrose and 3′-dehydro-α,α-trehalose. It has no activity with disaccharides in which the glucose is in β conformation, and greatly reduced activity with disaccharides with an unmodified 3′ position.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Hayano, K. and Fukui, S. Alpha-3-ketoglucosidase of Agrobacterium tumefaciens. J. Bacteriol. 101 (1970) 692–697. [DOI] [PMID: 5438043]
2.	Liu, H., Shiver, A.L., Price, M.N., Carlson, H.K., Trotter, V.V., Chen, Y., Escalante, V., Ray, J., Hern, K.E., Petzold, C.J., Turnbaugh, P.J., Huang, K.C., Arkin, A.P. and Deutschbauer, A.M. Functional genetics of human gut commensal Bacteroides thetaiotaomicron reveals metabolic requirements for growth across environments. Cell Rep. 34:108789 (2021). [DOI] [PMID: 33657378]

[EC 3.2.1.218 created 2022]