ExplorEnz: EC 3.2.1.225

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3.2.1.225

Accepted name:

D-arabinan exo α-(1,3)/(1,5)-arabinofuranosidase (non-reducing end)

Reaction:

Hydrolysis of terminal non-reducing α-D-arabinofuranoside residues in D-arabinans

Other name(s):

exo-α-D-arabinofuranosidase; DgGH172a; DgGH172b; DgGH172c; NocGH172; MycGH172; ExoMA1

Systematic name:

α-D-arabinofuranoside non-reducing end α-D-arabinofuranosidase (configuration-retaining)

Comments:

The enzyme hydrolyses α-D-arabinofuranosides with (1→3)- and (1→5)-linkages in D-arabinan core structure of lipoarabinomannan and arabinogalactan of mycobacterial cell wall. cf. EC 3.2.1.55, non-reducing end α-L-arabinofuranosidase; EC 3.2.1.224, D-arabinan exo β-(1,2)-arabinofuranosidase (non-reducing end); and EC 3.2.1.226, D-arabinan endo α-(1,5)-arabinofuranosidase.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

Al-Jourani, O., Benedict, S.T., Ross, J., Layton, A.J., van der Peet, P., Marando, V.M., Bailey, N.P., Heunis, T., Manion, J., Mensitieri, F., Franklin, A., Abellon-Ruiz, J., Oram, S.L., Parsons, L., Cartmell, A., Wright, G.SA., Basle, A., Trost, M., Henrissat, B., Munoz-Munoz, J., Hirt, R.P., Kiessling, L.L., Lovering, A.L., Williams, S.J., Lowe, E.C. and Moynihan, P.J. Identification of D-arabinan-degrading enzymes in mycobacteria. Nat. Commun. 14:2233 (2023). [DOI] [PMID: 37076525]

Shimokawa, M., Ishiwata, A., Kashima, T., Nakashima, C., Li, J., Fukushima, R., Sawai, N., Nakamori, M., Tanaka, Y., Kudo, A., Morikami, S., Iwanaga, N., Akai, G., Shimizu, N., Arakawa, T., Yamada, C., Kitahara, K., Tanaka, K., Ito, Y., Fushinobu, S. and Fujita, K. Identification and characterization of endo-α-, exo-α-, and exo-β-D-arabinofuranosidases degrading lipoarabinomannan and arabinogalactan of mycobacteria. Nat. Commun. 14:5803 (2023). [DOI] [PMID: 37726269]

[EC 3.2.1.225 created 2024]