EC |
3.2.1.35 |
Accepted name: |
hyaluronoglucosaminidase |
Reaction: |
Random hydrolysis of (1→4)-linkages between N-acetyl-β-D-glucosamine and D-glucuronate residues in hyaluronate |
Other name(s): |
hyaluronidase; hyaluronoglucosidase; chondroitinase; chondroitinase I |
Systematic name: |
hyaluronate 4-glycanohydrolase |
Comments: |
Also hydrolyses 1,4-β-D-glycosidic linkages between N-acetyl-galactosamine or N-acetylgalactosamine sulfate and glucuronic acid in chondroitin, chondroitin 4- and 6-sulfates, and dermatan. |
Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 37326-33-3 |
References: |
1. |
Meyer, K., Hoffman, P. and Linker, A. Hyaluronidases. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Ed.), The Enzymes, 2nd edn, vol. 4, Academic Press, New York, 1960, pp. 447–460. |
2. |
Rapport, M.M., Myer, K. and Linker, A. Analysis of the products formed on hydrolysis of hyaluronic acid by testicular hyaluronidase. J. Am. Chem. Soc. 73 (1951) 2416–2420. |
3. |
Weissmann, B. The transglycosylative action of testicular hyaluronidase. J. Biol. Chem. 216 (1955) 783–794. [PMID: 13271353] |
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[EC 3.2.1.35 created 1965, modified 1976, modified 2001 (EC 3.2.1.34 created 1965, incorporated 1972)] |
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