| EC |
3.2.1.45 |
| Accepted name: |
glucosylceramidase |
| Reaction: |
a D-glucosyl-N-acylsphingosine + H2O = D-glucose + a ceramide |
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For diagram of glycolipid biosynthesis, click here |
| Glossary: |
a ceramide = an N-acylsphingosine |
| Other name(s): |
psychosine hydrolase; glucosphingosine glucosylhydrolase; GlcCer-β-glucosidase; β-D-glucocerebrosidase; glucosylcerebrosidase; β-glucosylceramidase; ceramide glucosidase; glucocerebrosidase; glucosylsphingosine β-glucosidase; glucosylsphingosine β-D-glucosidase |
| Systematic name: |
D-glucosyl-N-acylsphingosine glucohydrolase |
| Comments: |
Also acts on glucosylsphingosine (cf. EC 3.2.1.62 glycosylceramidase). |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 37228-64-1 |
| References: |
| 1. |
Brady, R.O., Kanfer, J.N. and Shapiro, D. The metabolism of glucocerebrosides. I. Preparation and properties of a glucocerebroside-cleaving enzyme from spleen tissue. J. Biol. Chem. 240 (1966) 39–43. [PMID: 14253443] |
| 2. |
Vaccaro, A.M., Muscillo, M. and Suzuki, K. Characterization of human glucosylsphingosine glucosyl hydrolase and comparison with glucosylceramidase. Eur. J. Biochem. 146 (1985) 315–321. [DOI] [PMID: 3967661] |
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| [EC 3.2.1.45 created 1972] |
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