EC |
3.2.2.22 |
Accepted name: |
rRNA N-glycosylase |
Reaction: |
Hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes |
Other name(s): |
ribosomal ribonucleate N-glycosidase; nigrin b; RNA N-glycosidase; rRNA N-glycosidase; ricin; momorcochin-S; Mirabilis antiviral protein; momorcochin-S; gelonin; saporins |
Systematic name: |
rRNA N-glycohydrolase |
Comments: |
Ricin A-chain and related toxins show this activity. Naked rRNA is attacked more slowly than rRNA in intact ribosomes. Naked rRNA from Escherichia coli is cleaved at a corresponding position. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 113756-12-0 |
References: |
1. |
Endo, Y. and Tsurugi, K. The RNA N-glycosidase activity of ricin A-chain. The characteristics of the enzymatic activity of ricin A-chain with ribosomes and with rRNA. J. Biol. Chem. 263 (1988) 8735–8739. [PMID: 3288622] |
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[EC 3.2.2.22 created 1990, modified 2000] |
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