ExplorEnz: EC 3.2.2.26

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3.2.2.26

Accepted name:

futalosine hydrolase

Reaction:

futalosine + H₂O = dehypoxanthine futalosine + hypoxanthine

For diagram of the futalosine pathway, click here

Glossary:

futalosine = 3-(3-((3S,4R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9(6H)-yl)tetrahydrofuran-2-yl)propanoyl)benzoate
dehypoxanthine futalosine = 7-(3-carboxyphenyl)-D-ribo-7-dehydro-5,6-dideoxyheptose

Other name(s):

futalosine nucleosidase; MqnB (ambiguous)

Systematic name:

futalosine ribohydrolase

Comments:

This enzyme, which is specific for futalosine, catalyses the second step of a novel menaquinone biosynthetic pathway that is found in some prokaryotes.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc

References:

1.	Hiratsuka, T., Furihata, K., Ishikawa, J., Yamashita, H., Itoh, N., Seto, H. and Dairi, T. An alternative menaquinone biosynthetic pathway operating in microorganisms. Science 321 (2008) 1670–1673. [DOI] [PMID: 18801996]

[EC 3.2.2.26 created 2008]