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Your query returned 1 entry. Printable version
EC | 3.2.2.6 | ||||||||||||||
Accepted name: | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase | ||||||||||||||
Reaction: | NAD+ + H2O = ADP-D-ribose + nicotinamide (overall reaction) (1a) NAD+ = cyclic ADP-ribose + nicotinamide (1b) cyclic ADP-ribose + H2O = ADP-D-ribose |
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For diagram of cyclic ADP-ribose biosynthesis, click here | |||||||||||||||
Glossary: | ADP-D-ribose = adenosine 5′-(5-deoxy-D-ribofuranos-5-yl diphosphate) cyclic ADP-ribose = N1-(β-D-ribosyl)adenosine 5′(P1),5′′(P2)-cyclic diphosphate |
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Other name(s): | NAD+ nucleosidase; NADase (ambiguous); DPNase (ambiguous); DPN hydrolase (ambiguous); NAD hydrolase (ambiguous); nicotinamide adenine dinucleotide nucleosidase (ambiguous); NAD glycohydrolase (misleading); NAD nucleosidase (ambiguous); nicotinamide adenine dinucleotide glycohydrolase (misleading); CD38 (gene name); BST1 (gene name) | ||||||||||||||
Systematic name: | NAD+ glycohydrolase (cyclic ADP-ribose-forming) | ||||||||||||||
Comments: | This multiunctional enzyme acts on NAD+, catalysing both the synthesis and hydrolysis of cyclic ADP-ribose, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 2.4.99.20, 2′-phospho-ADP-ribosyl cyclase/2′-phospho-cyclic-ADP-ribose transferase. It is also able to act on β-nicotinamide D-ribonucleotide. cf. EC 3.2.2.5, NAD+ glycohydrolase. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9032-65-9 | ||||||||||||||
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