The Enzyme Database

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Accepted name: Xaa-Pro dipeptidase
Reaction: Hydrolysis of Xaa┼Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro
Other name(s): prolidase; imidodipeptidase; proline dipeptidase; peptidase D; γ-peptidase; X-Pro dipeptidase
Comments: A Mn2+-activated enzyme, in peptidase family M24 (methionyl aminopeptidase family); cytosolic from most animal tissues.
Links to other databases: BRENDA, EXPASY, Gene, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 9025-32-5
1.  Davis, N.C. and Smith, E.L. Purification and some properties of prolidase of swine kidney. J. Biol. Chem. 224 (1957) 261–275. [PMID: 13398404]
2.  Sjöström, H., Norén, O. and Josefsson, L. Purification and specificity of pig intestinal prolidase. Biochim. Biophys. Acta 327 (1973) 457–470. [DOI] [PMID: 4778946]
3.  Baksi, K. and Radhakrishnan, A.N. Purification and properties of prolidase (imidodipeptidase) from monkey small intestine. Indian J. Biochem. Biophys. 11 (1974) 7–11. [PMID: 4435812]
4.  Browne, P. and O'Cuinn, G. The purification and characterization of a proline dipeptidase from guinea pig brain. J. Biol. Chem. 258 (1983) 6147–6154. [PMID: 6853481]
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