The Enzyme Database

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Accepted name: lysosomal Pro-Xaa carboxypeptidase
Reaction: Cleavage of a -Pro┼Xaa bond to release a C-terminal amino acid
Other name(s): angiotensinase C; lysosomal carboxypeptidase C; peptidylprolylamino acid carboxypeptidase; aminoacylproline carboxypeptidase; prolyl carboxypeptidase; carboxypeptidase P; proline-specific carboxypeptidase P; PCP
Comments: A lysosomal peptidase active at acidic pH that inactivates angiotensin II. Inhibited by diisopropyl fluorophosphate. In peptidase family S28 (Pro-X carboxypeptidase family).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 9075-64-3
1.  Walter, R., Simmons, W.H. and Yoshimoto, T. Proline specific endo- and exopeptidases. Mol. Cell. Biochem. 30 (1980) 111–127. [PMID: 6991912]
2.  Odya, C.E. and Erdös, E.G. Human prolylcarboxypeptidase. Methods Enzymol. 80 (1981) 460–466. [PMID: 7341916]
[EC created 1972 as EC, transferred 1978 to EC]

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