| EC |
3.4.17.22 |
| Accepted name: |
metallocarboxypeptidase D |
| Reaction: |
Releases C-terminal Arg and Lys from polypeptides |
| Other name(s): |
carboxypeptidase D (cattle, human, mouse, rat); gp180 (duck) |
| Comments: |
Activated by Co2+; inhibited by [(2-guanidinoethyl)sulfanyl]butanedioate. Large molecule (180 kDa) because of presence of three copies of metallopeptidase domain. The product of the silver gene (Drosophila) is similar. A zinc metallopeptidase in peptidase family M14 (carboxypeptidase A family) |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 153967-26-1 |
| References: |
| 1. |
Kuroki, K., Eng, F., Ishikawa, T., Turck, C., Harada, F. and Ganem, D. gp180, a host cell glycoprotein that binds duck hepatitis B virus particles, is encoded by a member of the carboxypeptidase gene family. J. Biol. Chem. 270 (1995) 15022–15028. [DOI] [PMID: 9525948] |
| 2. |
Song, L.X. and Fricker, L.D. Purification and characterization of carboxypeptidase D, a novel carboxypeptidase E-like enzyme, from bovine pituitary. J. Biol. Chem. 270 (1995) 25007–25013. [DOI] [PMID: 7559630] |
| 3. |
Song, L.X. and Fricker, L.D. Tissue distribution and characterization of soluble and membrane-bound forms of metallocarboxypeptidase D. J. Biol. Chem. 271 (1996) 28884–28889. [DOI] [PMID: 8910535] |
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| [EC 3.4.17.22 created 1997] |
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