The Enzyme Database

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Accepted name: glutathione-S-conjugate glycine hydrolase
Reaction: a glutathione-S-conjugate + H2O = a [γ-glutamyl-L-cysteine]-S-conjugate + glycine
Other name(s): PCS1 (gene name); PRC1 (gene name); CPC (gene name); ATG42 (gene name); alr0975 (locus name)
Systematic name: glutathione-S-conjugate glycine hydrolase
Comments: The enzyme participates in a glutathione-mediated detoxification pathway found in plants, algae, fungi, and some bacteria. The enzymes from the plant Arabidopsis thaliana and the yeast Saccharomyces cerevisiae also catalyse the activity of EC, glutathione γ-glutamylcysteinyltransferase (phytochelatin synthase).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Beck, A., Lendzian, K., Oven, M., Christmann, A. and Grill, E. Phytochelatin synthase catalyzes key step in turnover of glutathione conjugates. Phytochemistry 62 (2003) 423–431. [PMID: 12620355]
2.  Grzam, A., Tennstedt, P., Clemens, S., Hell, R. and Meyer, A.J. Vacuolar sequestration of glutathione S-conjugates outcompetes a possible degradation of the glutathione moiety by phytochelatin synthase. FEBS Lett. 580 (2006) 6384–6390. [PMID: 17097087]
3.  Harada, E., von Roepenack-Lahaye, E. and Clemens, S. A cyanobacterial protein with similarity to phytochelatin synthases catalyzes the conversion of glutathione to γ-glutamylcysteine and lacks phytochelatin synthase activity. Phytochemistry 65 (2004) 3179–3185. [PMID: 15561184]
4.  Tsuji, N., Nishikori, S., Iwabe, O., Shiraki, K., Miyasaka, H., Takagi, M., Hirata, K. and Miyamoto, K. Characterization of phytochelatin synthase-like protein encoded by alr0975 from a prokaryote, Nostoc sp. PCC 7120. Biochem. Biophys. Res. Commun. 315 (2004) 751–755. [PMID: 14975765]
5.  Vivares, D., Arnoux, P. and Pignol, D. A papain-like enzyme at work: native and acyl-enzyme intermediate structures in phytochelatin synthesis. Proc. Natl. Acad. Sci. USA 102 (2005) 18848–18853. [PMID: 16339904]
6.  Wunschmann, J., Krajewski, M., Letzel, T., Huber, E.M., Ehrmann, A., Grill, E. and Lendzian, K.J. Dissection of glutathione conjugate turnover in yeast. Phytochemistry 71 (2010) 54–61. [PMID: 19897216]
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